File:Tyrosine-Binding-Protein-Sites-Regulate-the-Intracellular-Trafficking-and-Processing-of-Amyloid-pone.0161445.s004.ogv

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Tyrosine-Binding-Protein-Sites-Regulate-the-Intracellular-Trafficking-and-Processing-of-Amyloid-pone.0161445.s004.ogv (Ogg Theora video file, length 12 s, 466 × 463 pixels, 1.85 Mbps, file size: 2.63 MB)

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English: APP bearing the Y738A mutation traffics to lysosomes. SN56 cells were transiently transfected with βAPP Y738A-paGFP (green), LAMP1-mRFP (lysosome marker, red), and GalT-CFP (Golgi marker, blue). APP was photo-activated in the Golgi (blue) with 405nm light, alternating with imaging for 15 minutes (indicated by green word ‘Photo-activating’). Photo-activation ROIs in the Golgi are denoted by white circles in the video. Cells were then chased by imaging every 30 seconds for the indicated time.
Date
Source S3 Video from Tam J, Cobb M, Seah C, Pasternak S (2016). "Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway". PLOS ONE. DOI:10.1371/journal.pone.0161445. PMID 27776132. PMC: 5077117.
Author Tam J, Cobb M, Seah C, Pasternak S
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current09:00, 31 January 201712 s, 466 × 463 (2.63 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 360P 418 kbps Completed 11:08, 24 October 2018 9.0 s
VP9 240P 207 kbps Completed 11:08, 24 October 2018 7.0 s
WebM 360P 515 kbps Completed 09:00, 31 January 2017 5.0 s
QuickTime 144p (MJPEG) Not ready Unknown status

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