File:The epiphyseal growth plate and the chondro-osseous junction.jpg

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Description Fig. 6. The epiphyseal growth plate and the chondro-osseous junction. (A–C) LM and (D) TEM. (A, B) Longitudinal semi-thin sections (1 μm) depict the columnar arrangement of proliferating (pc) and hypertrophic chondrocytes (hc) and the underlying primary ossification centre (poc). (A) At the chondro-osseous junction (highlighted in yellow), osteoblasts (arrowheads) line the mineralized cartilage scaffold and in (B) capillaries (arrowheads) invade the lacunae of late hypertrophic chondrocytes. Toluidine blue stain. (C) TRAP staining. Chondroclasts (red staining) erode the mineralized cartilage and apparently allow the invasion of vessels into the lacunae. Arrowheads point to osteoblasts. The section is counterstained with haematoxylin. (D) Several late hypertrophic chondrocytes contain a shrunken nucleus (n) with condensed chromatin on its margin, rough endoplasmic reticulum (rer) and large amounts of electron dense material, presumable glycogen. The depicted chondrocyte is slightly detached from the cartilage matrix and does not contain any vacuoles. The ultrastructural features indicate that this cell undergoes apoptosis but not autophagy. All sections are from a two-week old mouse, and the bones are demineralized. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
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Source https://www.sciencedirect.com/science/article/pii/S0940960221000303?via%3Dihub Khan et al. Arthritis Research & Therapy (2020) 22:168 https://doi.org/10.1186/s13075-020-02259-z
Author Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi
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current14:46, 1 December 2024Thumbnail for version as of 14:46, 1 December 20242,508 × 1,891 (1.49 MB)Rasbak (talk | contribs){{Information |description=Fig. 6. The epiphyseal growth plate and the chondro-osseous junction. (A–C) LM and (D) TEM. (A, B) Longitudinal semi-thin sections (1 μm) depict the columnar arrangement of proliferating (pc) and hypertrophic chondrocytes (hc) and the underlying primary ossification centre (poc). (A) At the chondro-osseous junction (highlighted in yellow), osteoblasts (arrowheads) line the mineralized cartilage scaffold and in (B) capillaries (arrowheads) invade the lacunae of late...

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