File:Schematic drawing. The events during chondral osteogenesis in the long bones of mammls.jpg
Original file (2,175 × 3,270 pixels, file size: 586 KB, MIME type: image/jpeg)
Captions
Captions
Summary
[edit]
| Description | Fig. 7. Schematic drawing: the events during chondral osteogenesis in the long bones of mammals (A) Cartilage model. Mesenchymal cells differentiate into chondrocytes, synthesize extracellular matrix and form a cartilage model (weak purple) with the shape of the future bone. The perichondrium (p, green layer) covers the model. (B) Intramembranous ossification. The innermost membrane of the perichondrium directly forms the bone cuff (brown layer), triggering the mineralization of the hypertrophic cartilage (black). (C) Endochondral (intracartilaginous) ossification. From the periosteum (po), blood vessels (red), chondroclasts and early osteoblasts invade the cartilage. The chondroclasts degrade the cartilage matrix which causes the formation of the marrow cavity (mc) and a scaffold of mineralized cartilage (black dots in the mc). The epiphyseal growth plate is highlighted in yellow. (D) Establishment of the diaphyseal POC. Osteoblasts line the scaffold, synthesize osteoid and after its mineralization become entrapped in the bone matrix. Once the POC is established, the formation of the SOC is initiated by invasion of the vascularized cartilage canals (cc, red), followed by mineralization of the hypertrophic cartilage (black). Asterisks indicate layers of hypertrophic chondrocytes that act as the surface growth plate. (E) Establishment of the epiphyseal SOC. The cartilage canals form a complex network in the epiphysis, and the canals’ osteogenic cells contribute to the establishment of the SOC. (A–F) Bone growth. With age the growth plates get thinner, and once bone growth ceases, the original cartilage model is replaced by bone but at the bone endings the articular cartilage (ac) remains. ac = articular cartilage, cb = cortical bone; cc = cartilage canal; dp = diaphysis; e = epiphysis; mc = marrow cavity; mp = metaphysis; p = perichondrium; po = periosteum; poc = primary ossification centre; soc = secondary ossification centre; tb = trabecular bone. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) |
| Date | |
| Source | https://www.sciencedirect.com/science/article/pii/S0940960221000303?via%3Dihub Khan et al. Arthritis Research & Therapy (2020) 22:168 https://doi.org/10.1186/s13075-020-02259-z |
| Author | Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi |
|
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.
|
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Licensing
[edit]
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:16, 1 December 2024 | | 2,175 × 3,270 (586 KB) | Rasbak (talk | contribs) | {{Information |description=Fig. 7. Schematic drawing: the events during chondral osteogenesis in the long bones of mammals (A) Cartilage model. Mesenchymal cells differentiate into chondrocytes, synthesize extracellular matrix and form a cartilage model (weak purple) with the shape of the future bone. The perichondrium (p, green layer) covers the model. (B) Intramembranous ossification. The innermost membrane of the perichondrium directly forms the bone cuff (brown layer), triggering the mine... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
