File:Rapid-and-Direct-Transport-of-Cell-Surface-APP-to-the-Lysosome-defines-a-novel-selective-pathway-1756-6606-3-11-S2.ogv

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Rapid-and-Direct-Transport-of-Cell-Surface-APP-to-the-Lysosome-defines-a-novel-selective-pathway-1756-6606-3-11-S2.ogv (Ogg Theora video file, length 25 s, 320 × 240 pixels, 179 kbps, file size: 545 KB)

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Description
English: Image stack of an immunostained mouse neuron demonstrating APP in the lysosome. Cultured mouse neurons were fixed and immunolabeled with anti-APP (green) and anti-LAMP1 antibodies (red) and Hoechst nuclear stain (blue). Image stack was acquired on a Zeiss LSM510 confocal microscope. The first segment shows βAPP-CFP in green. The second segment of the video shows LAMP1-mRFP overlaid in red. In the third segment, a channel showing the colocalization of the brightest 2% of red and green pixels is overlaid in white. QuickTime video was generated using Imaris 6.1.5 software to perform volume rendering and animation.
Date
Source Lorenzen A, Samosh J, Vandewark K, Anborgh P, Seah C, Magalhaes A, Cregan S, Ferguson S, Pasternak S (2010). "Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway". Molecular Brain. DOI:10.1186/1756-6606-3-11. PMID 20409323. PMC: 2868040.
Author Lorenzen A, Samosh J, Vandewark K, Anborgh P, Seah C, Magalhaes A, Cregan S, Ferguson S, Pasternak S
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This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
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Date/TimeThumbnailDimensionsUserComment
current00:08, 20 November 201225 s, 320 × 240 (545 KB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 240P 72 kbps Completed 00:11, 17 October 2018 8.0 s
WebM 360P 89 kbps Completed 07:48, 2 December 2023 2.0 s
QuickTime 144p (MJPEG) 452 kbps Completed 14:53, 12 October 2024 1.0 s

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