File:Prolonged posterior e-m signaling in Tbx2-deficient hindlimbs.png
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Figure 2. Prolonged posterior e-m signaling in Tbx2-deficient hindlimbs. Whole-mount in situ hybridization analysis of Fgf4, Fgf9, Fgf17, Shh and Fgf8 expression in E10.5 (A–E), E11.5 (F–J) and E12.5 (K–O) wild-type and Tbx2−/− hindlimbs. (F, G, H) Arrowheads show prolonged AER expression of Fgf4/9/17 in the posterior limb bud at E11.5. (K, N) Arrowheads show maintenance of Fgf4 and Shh expression at E12.5 in Tbx2−/− hindlimbs. Fgf8 expression is unchanged in Tbx2-mutant limb buds |
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| Source | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003467 Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. (2013) Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1. PLoS Genet 9(4): e1003467. https://doi.org/10.1371/journal.pgen.1003467 |
| Author | Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. |
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© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| current | 21:07, 15 November 2024 | | 1,802 × 1,562 (4.3 MB) | Rasbak (talk | contribs) | {{Information |Description=Figure 2. Prolonged posterior e-m signaling in Tbx2-deficient hindlimbs. Whole-mount in situ hybridization analysis of Fgf4, Fgf9, Fgf17, Shh and Fgf8 expression in E10.5 (A–E), E11.5 (F–J) and E12.5 (K–O) wild-type and Tbx2−/− hindlimbs. (F, G, H) Arrowheads show prolonged AER expression of Fgf4/9/17 in the posterior limb bud at E11.5. (K, N) Arrowheads show maintenance of Fgf4 and Shh expression at E12.5 in Tbx2−/− hindlimbs. Fgf8 expression is unchanged in Tbx2-... |
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