File:Pleiotropic-Effects-of-Sox2-during-the-Development-of-the-Zebrafish-Epithalamus-pone.0087546.s013.ogv
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[edit]DescriptionPleiotropic-Effects-of-Sox2-during-the-Development-of-the-Zebrafish-Epithalamus-pone.0087546.s013.ogv |
English: Upregulation of Notch results in a broader domain of sox2 expression at 20 ss. sox2 (red) is expressed in undifferentiated GFP-positive (green) pineal cells of Tg(flh:GFP) embryos, but it is downregulated in post-mitotic isl1-expressing cells (blue), in heat-shocked control embryos (left panel). Heat-shock of Tg(hs:Gal4);Tg(UAS:Notch-intra) (right panel) results in upregulation of Notch signaling. Upregulation of Notch leads to fewer isl1 cells and thus sox2 is expressed in a broader domain. Navigation through the optical stacks starting with the dorsal-most optical section of the pineal anlage and moving ventrally. |
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Source | Movie S2 from Pavlou S, Astell K, Kasioulis I, Gakovic M, Baldock R, van Heyningen V, Coutinho P (2014). "Pleiotropic Effects of Sox2 during the Development of the Zebrafish Epithalamus". PLOS ONE. DOI:10.1371/journal.pone.0087546. PMC: 3909122. | ||
Author | Pavlou S, Astell K, Kasioulis I, Gakovic M, Baldock R, van Heyningen V, Coutinho P | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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current | 21:56, 5 February 2014 | 2.7 s, 1,398 × 695 (278 KB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Pavlou S, Astell K, Kasioulis I, Gakovic M, Baldock R, van Heyningen V, Coutinho P |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Upregulation of Notch results in a broader domain of sox2 expression at 20 ss. sox2 (red) is expressed in undifferentiated GFP-positive (green) pineal cells of Tg(flh:GFP) embryos, but it is downregulated in post-mitotic isl1-expressing cells (blue), in heat-shocked control embryos (left panel). Heat-shock of Tg(hs:Gal4);Tg(UAS:Notch-intra) (right panel) results in upregulation of Notch signaling. Upregulation of Notch leads to fewer isl1 cells and thus sox2 is expressed in a broader domain. Navigation through the optical stacks starting with the dorsal-most optical section of the pineal anlage and moving ventrally. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014 |
Categories:
- Regulatory networks
- Videos of developmental biology
- Molecular development
- Organism development
- Cell differentiation
- Cell fate determination
- Animal genetics
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- Genetic predispositions to diseases
- Functional genomics
- Model organisms
- Animal models of disease
- Videos of developmental neuroscience
- Media from PLOS ONE
- Upregulation