File:Neuron–SGC interactions in RA.png
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| Description | Figure 5. Neuron–satellite glial cell interactions in rheumatoid arthritis. (A) Sections of human ganglion spinale (DRG) showing immunostaining for LPA1, the SGC marker glutamine synthetase (GS), and the nuclear dye DAPI (blue). The combined image (right) shows clear colocalization of the LPA receptor LPA1 and GS in SGCs. Scale bar, 50 µm. (B) Schematic of lysophosphatidic acid (LPA) signaling in collagen antibody-induced arthritis (CAIA). In the CAIA model, autotaxin (ATX) is elevated in DRG neurons, possibly in response to sensitizing stimuli such as joint inflammation and immune complex activation of nociceptors. ATX increases the levels of LPA, which activates SGCs that express LPA1, leading to SGC activation. Activated SGCs produce increased levels of pronociceptive cytokines and NGF, which can then act on the corresponding receptors in the neurons. This further promotes nociceptor excitability, leading to the development of chronic pain. Reprinted under Creative Commons Attribution (CC-BY) license from Su et al. [80] Brain Behav. Immun., Elsevier, 2022. |
| Date | |
| Source | https://www.mdpi.com/2073-4409/13/7/566 Hanani, M. Satellite Glial Cells in Human Disease. Cells 2024, 13, 566. https://doi.org/10.3390/cells13070566 |
| Author | Hanani, M. |
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https://www.mdpi.com/2073-4409/13/7/566 Hanani, M. Satellite Glial Cells in Human Disease. Cells 2024, 13, 566. https://doi.org/10.3390/cells13070566, was reviewed on 12 October 2024 by reviewer Metacladistics, who confirmed that it was available there under the stated license on that date.
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© 2024 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:51, 8 October 2024 | | 2,567 × 3,640 (1.14 MB) | Rasbak (talk | contribs) | {{Information |description=Figure 5. Neuron–satellite glial cell interactions in rheumatoid arthritis. (A) Sections of human ganglion spinale (DRG) showing immunostaining for LPA1, the SGC marker glutamine synthetase (GS), and the nuclear dye DAPI (blue). The combined image (right) shows clear colocalization of the LPA receptor LPA1 and GS in SGCs. Scale bar, 50 µm. (B) Schematic of lysophosphatidic acid (LPA) signaling in collagen antibody-induced arthritis (CAIA). In the CAIA model, autotax... |
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