File:NFKBID interaction.tiff

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English: Interaction model of NFKBID (purple) with the p50 homodimer (green and blue) bound to DNA (red). The complex was studied by molecular docking experiments. The NFKBID-p50/p50 complex interacts electrostatically with phosphates of the DNA backbone. Therefore, the protein complex is not able to exit the nucleus. The mainly positively charged surface of NFKBID close to DNA blocks the exchange of the p50/p50 dimer with other dimers, that are activating transcription factors.
Date
Source Manavalan B, Basith S, Choi Y-M, Lee G, Choi S (2010) Structure-Function Relationship of Cytoplasmic and Nuclear IκB Proteins: An In Silico Analysis. PLoS ONE 5(12): e15782. doi:10.1371/journal.pone.0015782
Author Manavalan et al.

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current17:32, 23 December 2014Thumbnail for version as of 17:32, 23 December 20141,236 × 1,263 (5.96 MB)JSFrei (talk | contribs)User created page with UploadWizard

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