File:Mouse embryo Cellular expansion and morphology of CSF1R+ progenitors.jpg

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Description Fig 6 (2 correction). Cellular expansion and morphology of CSF1R+ progenitors. a Schematic graph for the Csf1rMerCreMer:Rosa26eYFP mouse model with OH-TAM pulse labeling at E7.5 or E8.5 (red arrows) and subsequent analyses at indicated time points (black arrows). b, c Fluorescence pictures of E10.5 YS and embryo after OH-TAM pulse at E7.5 or E8.5 as indicated (b) with corresponding quantifications c; *** p < 0.001 (two-tailed Mann–Whitney test); median ± IQR. d Fluorescent pictures in the YS and embryo at E8.5, E9.0 and E9.5 with OH-TAM injection 24 h earlier. e, f Fluorescence pictures of a E12.5 YS and different embryonic regions after OH-TAM pulse labeling on E8.5 (e) with corresponding quantification of cluster size (f); *** p < 0.001 (Kruskal–Wallis test with Dunn’s multiple comparisons test); median ± IQR. g Quantification of intravascular cells at indicated time points in an average-sized vessel; median ± IQR. h Fluorescence pictures of a E10.25 YS in a Csf1rMerCreMer:Rosa26tdTomato (red):Cx3cr1GFP/+ (green) mouse model with OH-TAM pulse labeling at E8.5. Additional staining for F4/80 (purple) and CD31 (turquoise). i, j Adult liver sections of Csf1rMerCreMer:Rosa26eYFP mice, pulse-labeled at E8.5 (i) with additional stainings for CD31 (red) and DAPI (blue) (j). Scale bars are 100 µm (b, d, e, j), 1 mm (i), 50 µm (h)
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Source https://www.nature.com/articles/s41467-018-06065-9/figures/2 Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nat Commun 9, 75 (2018). https://doi.org/10.1038/s41467-017-02492-2
Author Stremmel, C., Schuchert, R., Wagner, F. et al.
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current21:05, 21 April 2024Thumbnail for version as of 21:05, 21 April 20241,983 × 1,946 (2.73 MB)Rasbak (talk | contribs){{Information |description=Fig 6 (2 correction). Cellular expansion and morphology of CSF1R+ progenitors. a Schematic graph for the Csf1r<sup>MerCreMer</sup>:Rosa26<sup>eYFP</sup> mouse model with OH-TAM pulse labeling at E7.5 or E8.5 (red arrows) and subsequent analyses at indicated time points (black arrows). b, c Fluorescence pictures of E10.5 YS and embryo after OH-TAM pulse at E7.5 or E8.5 as indicated (b) with corresponding quantifications c; *** p < 0.001 (two-tailed Mann–Whitney test)...

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