File:Molecular determinants of the differentiation of macrophages and osteoclasts.jpg
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| Description | Figure 4 Molecular determinants of the differentiation of macrophages and osteoclasts. Macrophages and osteoclasts are the result of two competing differentiations of myeloid progenitor. Under the stimulation of M-CSF, myeloid progenitor differentiates into macrophages. Under the dual stimulation of M-CSF and RANKL, myeloid progenitor differentiates into osteoclasts. The differentiation of macrophages into osteoclasts is regulated by multiple factors. PPARγ, ERRα, PGC-1β, Ndusf4 and maternal VLDLR are currently widely recognized. The combination of RANK and its ligand and the combination of M-CSF and c-fms trigger the activation of multiple downstream pathways of osteoclasts precursor to induce osteoclasts differentiation. |
| Date | |
| Source | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.664871/full Yao Y, Cai X, Ren F, Ye Y, Wang F, Zheng C, Qian Y and Zhang M (2021) The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases. Front. Immunol. 12:664871. doi: 10.3389/fimmu.2021.664871 |
| Author | Yao Y, Cai X, Ren F, Ye Y, Wang F, Zheng C, Qian Y and Zhang M |
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© 2021 Yao, Cai, Ren, Ye, Wang, Zheng, Qian and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 10:51, 5 December 2024 | | 1,772 × 1,062 (184 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 4 Molecular determinants of the differentiation of macrophages and osteoclasts. Macrophages and osteoclasts are the result of two competing differentiations of myeloid progenitor. Under the stimulation of M-CSF, myeloid progenitor differentiates into macrophages. Under the dual stimulation of M-CSF and RANKL, myeloid progenitor differentiates into osteoclasts. The differentiation of macrophages into osteoclasts is regulated by multiple factors. PPARγ, ERRα, P... |
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