File:Molecular-Mechanism-of-Allosteric-Communication-in-Hsp70-Revealed-by-Molecular-Dynamics-Simulations-pcbi.1002844.s012.ogv

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Original file (Ogg multiplexed audio/video file, Theora/Vorbis, length 40 s, 856 × 480 pixels, 1.9 Mbps overall, file size: 9.12 MB)

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English: Geometric strain analysis of open DnaK bound to ADP. In the open DnaK bound to ADP, a significant strain accumulation indicates approaching between residues of loop 220–224, and the opposite loop area of βSBD, residues 447–452, that progressively rearranges its contact with the NBD. Strain increases at hinges at the C-terminal end, D385, which is propagated through linker and D393 to the SBD, inducing the motion of βSBD. This event is followed by strain accumulation and release at the interface between NBD subdomain IB and the contacting αSBD (NBD residue 164 and SBD residues 505, 517, 522 and 525). As a consequence, segment 518–528, detaches from the NBD. Interestingly, in the presence of ADP strain increases at loop 195.
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Source Video S2 from Chiappori F, Merelli I, Colombo G, Milanesi L, Morra G (2012). "Molecular Mechanism of Allosteric Communication in Hsp70 Revealed by Molecular Dynamics Simulations". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1002844. PMID 23300424. PMC: 3531320.
Author Chiappori F, Merelli I, Colombo G, Milanesi L, Morra G
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current11:40, 20 January 201340 s, 856 × 480 (9.12 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 480P 1.02 Mbps Completed 16:51, 3 September 2018 59 s
VP9 360P 507 kbps Completed 16:51, 3 September 2018 38 s
VP9 240P 257 kbps Completed 16:51, 3 September 2018 31 s
WebM 360P 506 kbps Completed 12:06, 20 January 2013 46 s
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