File:Model of Tbx2 function in the posterior hindlimb mesenchyme.png
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Figure 7. Model of Tbx2 function in the posterior hindlimb mesenchyme. (A) During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loop. Following proliferative expansion of ZPA-derived cells, a broadened Tbx2 expression (blue) causes Grem1 repression. Progressive displacement of Grem1-secreting cells from the AER terminates e-m signaling (E11.5, dotted arrows). The diagrams illustrate these dynamic signaling activities. (B) Failure of Grem1 repression in Tbx2-deficient hindlimbs causes prolonged e-m signaling. The dotted line shows the posterior limit of Grem1 expression in the wild-type. Impaired termination of outgrowth reduces apoptosis and causes expansion of the digit4 condensation (E12.5, grey regions). |
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| Source | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003467 Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. (2013) Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1. PLoS Genet 9(4): e1003467. https://doi.org/10.1371/journal.pgen.1003467 |
| Author | Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. |
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© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| current | 21:23, 15 November 2024 | | 1,731 × 1,566 (311 KB) | Rasbak (talk | contribs) | {{Information |Description=Figure 7. Model of Tbx2 function in the posterior hindlimb mesenchyme. (A) During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loop. Following proliferative expansion of ZPA-derived cells, a broadened Tbx2 expression (blue) causes Grem1 repression. Progressive displacement of Grem1-secreting cells from the AER terminates e-m signaling (E11... |
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