File:Model for cloacal septation.png

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Description Figure 7. Model for cloacal septation. (A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14. doi:10.1371/journal.pone.0029372.g007
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Xu K, Wu X, Shapiro E, Huang H, Zhang L, Hickling D, et al. (2012) Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation. PLoS ONE 7(1): e29372.

doi:10.1371/journal.pone.0029372
Author Kun Xu, Xinyu Wu, Ellen Shapiro, Honging Huang, Lixia Zhang, Duane Hickling, Yan Deng, Peng Lee, Juan Li, Herbert Lepor, Irina Grishina
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© 2012 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This file, which was originally posted to PLos ONE, was reviewed on 24 July 2024 by reviewer Geohakkeri, who confirmed that it was available there under the stated license on that date.

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current17:39, 24 July 2024Thumbnail for version as of 17:39, 24 July 20242,080 × 1,414 (996 KB)Rasbak (talk | contribs){{Information |description='''Figure 7. Model for cloacal septation.''' (A) E11.5 ''Bmp7<sup>lacZ/+</sup>'' embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apica...

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