File:Metabolic determinants of the differentiation osteoclasts.jpg
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| Description | Figure 5 Metabolic determinants of the differentiation osteoclasts. Experiments with primary bone marrow macrophages in Relb or Asxl2-deficient mice show that PGC-1β plays a vital role in the mitochondrial biogenesis of osteoclasts. However, in addition to initiating the expression of osteoclasts genes, c-fos-mediated activation of NFATc1 is also required. These indicate that although mitochondrial biogenesis and osteoclasts differentiation are independent processes, both require the production of functional osteoclasts. |
| Date | |
| Source | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.664871/full Yao Y, Cai X, Ren F, Ye Y, Wang F, Zheng C, Qian Y and Zhang M (2021) The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases. Front. Immunol. 12:664871. doi: 10.3389/fimmu.2021.664871 |
| Author | Yao Y, Cai X, Ren F, Ye Y, Wang F, Zheng C, Qian Y and Zhang M |
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© 2021 Yao, Cai, Ren, Ye, Wang, Zheng, Qian and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 10:54, 5 December 2024 | | 1,772 × 1,034 (212 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 5 Metabolic determinants of the differentiation osteoclasts. Experiments with primary bone marrow macrophages in Relb or Asxl2-deficient mice show that PGC-1β plays a vital role in the mitochondrial biogenesis of osteoclasts. However, in addition to initiating the expression of osteoclasts genes, c-fos-mediated activation of NFATc1 is also required. These indicate that although mitochondrial biogenesis and osteoclasts differentiation are independent processes... |
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