File:Loading Supports Osteoblast Differentiation and Suppresses Osteoclast Differentiation.png

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Description FIGURE 1. Loading Supports Osteoblast Differentiation and Suppresses Osteoclast Differentiation. In unloaded bone, sclerostin and RANKL expression is upregulated, supporting osteoclastogenesis and resorption. Following load, osteoblast and osteocyte differentiation increases, while osteoblast apoptosis and osteoclast differentiation decreases, leading to bone matrix deposition. Osteoblasts may embed and mature into osteocytes within the newly formed bone or may transition to quiescent bone lining cells on the newly formed bone surface. Bolded arrows and green chevrons indicate upregulated pathways, red chevrons indicate downregulated pathways.
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Source https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1364694/full Buck HV and Stains JP (2024) Osteocyte-mediated mechanical response controls osteoblast differentiation and function. Front. Physiol. 15:1364694. doi: 10.3389/fphys.2024.1364694
Author Buck HV and Stains JP
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© 2024 Buck and Stains. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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current21:28, 11 December 2024Thumbnail for version as of 21:28, 11 December 20241,639 × 528 (637 KB)Rasbak (talk | contribs){{Information |Description=FIGURE 1. Loading Supports Osteoblast Differentiation and Suppresses Osteoclast Differentiation. In unloaded bone, sclerostin and RANKL expression is upregulated, supporting osteoclastogenesis and resorption. Following load, osteoblast and osteocyte differentiation increases, while osteoblast apoptosis and osteoclast differentiation decreases, leading to bone matrix deposition. Osteoblasts may embed and mature into osteocytes within the newly formed bone or may tran...

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