File:In-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s005.ogv
In-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s005.ogv (Ogg Theora video file, length 11 s, 485 × 487 pixels, 1.52 Mbps, file size: 1.93 MB)
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[edit]DescriptionIn-Vivo-Imaging-Reveals-Distinct-Inflammatory-Activity-of-CNS-Microglia-versus-PNS-Macrophages-in-a-pone.0017910.s005.ogv |
English: Lack of microglial reaction after single axon transection in the lateral column of a clinical SOD1G93A mouse. This video sequence (145-minute) lasts from 25 minutes before to 120 minutes after an axonal transection in a 120-day-old mutant mouse. It shows a highly reduced microglial reaction towards the tissue lesion (note the autofluorescence in the image center; arrow). The axonal transection led to degeneration of the axon at both sides of the injury without any apparent contribution of microglia. Note the increased microglial activity including numerous engulfments and continuous ameboid migration independent of the injury setting. The frame rate of the video is 115 seconds per MIP. Scale bar, 20 µm. |
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Source | Video S5 from Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C (2011). "In Vivo Imaging Reveals Distinct Inflammatory Activity of CNS Microglia versus PNS Macrophages in a Mouse Model for ALS". PLOS ONE. DOI:10.1371/journal.pone.0017910. PMID 21437247. PMC: 3060882. | ||
Author | Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 21:59, 28 May 2013 | 11 s, 485 × 487 (1.93 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Dibaj P, Steffens H, Zschuntzsch J, Nadrigny F, Schomburg E, Kirchhoff F, Neusch C |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2011 |