File:Glioblastoma-A-Pathogenic-Crosstalk-between-Tumor-Cells-and-Pericytes-pone.0101402.s016.ogv
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Glioblastoma-A-Pathogenic-Crosstalk-between-Tumor-Cells-and-Pericytes-pone.0101402.s016.ogv (Ogg Theora video file, length 11 s, 400 × 476 pixels, 840 kbps, file size: 1.1 MB)
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[edit]DescriptionGlioblastoma-A-Pathogenic-Crosstalk-between-Tumor-Cells-and-Pericytes-pone.0101402.s016.ogv |
English: Actin-enriched flectopodia are associated with modifications in pericyte contractility. Confocal video showing GFP-actin-U87 cells (green) interacting with pericytes plated a on a laminin-coated silicone substrate. The contact of actin-enriched extensions of a GBM cell with the substrate (white arrows) is linked to new wrinkle-formation (red arrows), indicative of altered pericyte contractility. Yellow arrows point to substrate-relaxation following the retraction of the cell extension. Cyan arrows point to a GFPactin+-cytoplasmic fragment (which varies between 3.6 and 4 µm in diameter, lines indicate the trajectory), moving onto the substrate in tight contact with pericytes. Δtime: 7 minutes; time: 2 hour 30 min; rate: 2 fps. |
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Source | Movie S5 from Caspani E, Crossley P, Redondo-Garcia C, Martinez S (2014). "Glioblastoma: A Pathogenic Crosstalk between Tumor Cells and Pericytes". PLOS ONE. DOI:10.1371/journal.pone.0101402. PMID 25032689. PMC: 4102477. | ||
Author | Caspani E, Crossley P, Redondo-Garcia C, Martinez S | ||
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 19:06, 14 October 2016 | 11 s, 400 × 476 (1.1 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Caspani E, Crossley P, Redondo-Garcia C, Martinez S |
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Usage terms | http://creativecommons.org/licenses/by/4.0/ |
Image title | Actin-enriched flectopodia are associated with modifications in pericyte contractility. Confocal video showing GFP-actin-U87 cells (green) interacting with pericytes plated a on a laminin-coated silicone substrate. The contact of actin-enriched extensions of a GBM cell with the substrate (white arrows) is linked to new wrinkle-formation (red arrows), indicative of altered pericyte contractility. Yellow arrows point to substrate-relaxation following the retraction of the cell extension. Cyan arrows point to a GFPactin+-cytoplasmic fragment (which varies between 3.6 and 4 µm in diameter, lines indicate the trajectory), moving onto the substrate in tight contact with pericytes. Δtime: 7 minutes; time: 2 hour 30 min; rate: 2 fps. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2014 |
Categories:
- Microscopic videos of cells expressing GFP-actin
- Cell motility
- Videos of CD44
- Videos of glioblastoma
- Tumor cell line
- Cell surface extensions
- Nude mice
- Transgenic mice
- Neoplasm transplantation
- Neoplastic stem cells
- Neovascularization
- RNA interference
- Small interfering RNA
- Heterologous transplantation
- Videos of CDC42
- Media from PLOS ONE
- Pericyte