File:F3.medium.gif

English: FIGURE 3.

Relationships between 11C-(R)-PK11195 BPND and neuropsychologic symptoms in CFS/ME patients. Top row: Statistical parametric maps of correlations between 11C-(R)-PK11195 BPND in amygdala (A), hippocampus (B), and thalamus (C) and cognitive impairment, depression, and pain scores, respectively. Anatomic locations were mapped on template coronal brains. Bottom row: Scatterplots of 11C-(R)-PK11195 BPND in amygdala (−22, −2, 14) and cognitive impairment score (A), 11C-(R)-PK11195 BPND in hippocampus (26, −14, −16) and depression (CES-D) score (B), and 11C-(R)-PK11195 BPND in thalamus (−10, −18, 8) and pain score (C). Pearson coefficient value (r) and P value are shown for each relation. Scales show t values.

In the CFS/ME group, the SPM correlation analysis revealed that 11C-(R)-PK11195 BPND in the amygdala was positively correlated with cognitive impairment score (Fig. 3A), 11C-(R)-PK11195 BPND in the hippocampus was positively correlated with CES-D score (Fig. 3B), and 11C-(R)-PK11195 BPND in the thalamus tended to be correlated positively with pain score (voxel level, P < 0.005; cluster level, P > 0.05; Fig. 3C). There were no other correlations between 11C-(R)-PK11195 BPND in any brain regions and other parameters (age, duration of disease, VAS score of fatigue sensation, score of Chalder fatigue scale, or cytokine concentration).^[1]