File:Estimating-Dose-Painting-Effects-in-Radiotherapy-A-Mathematical-Model-pone.0089380.s006.ogv

English: Time evolution of a heterogeneous tumor growth (where CCs and CSCs are present) for the low migration case with and CSC cycle duration equal to 48 h. Tumor growth is allowed unchecked from a size of about 105 cells until about 106 cells are present. Then, a heterogeneous radiation therapy consisting of 3.3 Gy in the inner sphere and 2.0 Gy in the rest of the tumor is delivered. Treatment sessions are scheduled along 6 weeks, separated by 24 hours intervals except for weekends, where a 72 hours interval is allowed. Depicted in dark and light green (respectively, dark and light red) are proliferating and quiescent CCs (respectively, proliferating and quiescent CSCs). Dead cells are represented in black. See Tables 2 and 4 in the article for further details.