File:Ectopic Tbx2 represses Grem1 and disrupts e-m signaling in the limb.png
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Figure 6. Ectopic Tbx2 represses Grem1 and disrupts e-m signaling in the limb. (A–D) Skeletal preparations of E18.5 fore- and hindlimbs from wild-type and Prrx1-TBX2 (Prrx1-cre/+;HprtTBX2/Y) embryos. Insets show morphology of the autopod. Asterisks indicate reduced scapula in (B), and pelvic girdle in (D). Blue arrow in (D) shows the reduced femur. Abbreviations are: F, femur; Fi, fibula; H, humerus; Pg, pelvic gridle; R, radius; U, ulna; S, scapula; Ti, tibia. (E–H) Detection of apoptosis by Lysotracker Red staining in wild-type and Prrx1-TBX2 forelimbs. White arrowheads in (F) indicate increased mesenchymal apoptosis beneath the AER. White arrow in (G) shows apoptosis in the proximal mesenchyme of wild-type limbs. White boxes indicate magnified regions. (I–T) Whole-mount in situ hybridization analysis of Grem1, Fgf4, Shh, Msx1 and Msx2 expression in E12.5 and E10.5 wild-type and Prrx1-TBX2 forelimb buds. Green and red arrowheads highlight complementary expression of Grem1 and Msx1/2. |
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| Source | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003467 Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. (2013) Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1. PLoS Genet 9(4): e1003467. https://doi.org/10.1371/journal.pgen.1003467 |
| Author | Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. |
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© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| current | 21:21, 15 November 2024 | | 1,312 × 2,177 (3.47 MB) | Rasbak (talk | contribs) | {{Information |Description=Figure 6. Ectopic Tbx2 represses Grem1 and disrupts e-m signaling in the limb. (A–D) Skeletal preparations of E18.5 fore- and hindlimbs from wild-type and Prrx1-TBX2 (Prrx1-cre/+;HprtTBX2/Y) embryos. Insets show morphology of the autopod. Asterisks indicate reduced scapula in (B), and pelvic girdle in (D). Blue arrow in (D) shows the reduced femur. Abbreviations are: F, femur; Fi, fibula; H, humerus; Pg, pelvic gridle; R, radius; U, ulna; S, scapula; Ti, tibia. (E–... |
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