File:Dysregulated neuronal maturation in Fmr1 KO ganglion spinale (DRG).jpg
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| Description | Figure 4. Dysregulated neuronal maturation in Fmr1 KO ganglion spinale (DRG). (A) Mean expression of the progenitor markers Sox10, Fabp7, Notch1, and Foxd3 in WT (black) and Fmr1 KO (red). (B) Representative immunofluorescence images of DRG sections from WT and Fmr1 KO mice co-stained with TUJ1 (magenta) and the SGC marker FABP7 (green). n = 3 biologically independent animals. Scale bar: 50 μm. (C) Representative images of fluorescence intensity of FABP7/TUJ1 measured across neuron-satellite glial cell units (white line in inset image). (D) Percentage of neurons with detectable FABP7 expression in WT and Fmr1 KO. n = 3 biologically independent animals, 10–15 cells from each animal were used for measurements. (E) Trajectory analysis of small/medium neurons colored by genotype. |
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| Source | https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2021.796070/full Avraham O, Deng P-Y, Maschi D, Klyachko VA and Cavalli V (2022) Disrupted Association of Sensory Neurons With Enveloping Satellite Glial Cells in Fragile X Mouse Model. Front. Mol. Neurosci. 14:796070. doi: 10.3389/fnmol.2021.796070 |
| Author | Avraham O, Deng P-Y, Maschi D, Klyachko VA and Cavalli V |
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© 2022 Avraham, Deng, Maschi, Klyachko and Cavalli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 23:57, 8 October 2024 | | 4,550 × 2,742 (771 KB) | Rasbak (talk | contribs) | == {{int:filedesc}} == {{Information |description=Figure 4. Dysregulated neuronal maturation in Fmr1 KO ganglion spinale (DRG). (A) Mean expression of the progenitor markers Sox10, Fabp7, Notch1, and Foxd3 in WT (black) and Fmr1 KO (red). (B) Representative immunofluorescence images of DRG sections from WT and Fmr1 KO mice co-stained with TUJ1 (magenta) and the SGC marker FABP7 (green). n = 3 biologically independent animals. Scale bar: 50 μm. (C) Representative images of fluorescence intensi... |
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