File:CuracinA Biosynthetic Pathway.pdf

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English: The figure displays the biosynthetic pathway of Curacin A, a hybrid polyketide synthase (PKS) non-ribosomal peptide synthase (NRPS) derived natural product. This pathway consists of multiple genes that encode modules with individual domains that catalyze successive enzymatic reactions to produce a natural product. The figure demonstrates the main 13 modules necessary for the synthesis and offloading of Curacin A by the cyanobacterium Lyngbya Majuscula.


AT=Acyl Transferase (loading domain) KS=ketosynthase CP=Carrier Protein HaI=Halogenas HCS=HMG Coa Synthase KR=ketoreductase DH=Dehydratase ER=Enoyl Reductase ST=Sulfotransferase TE=Thioesterase A=Adenylation Domain Cy=Cyclization/Condensation Domain PCP=Peptidyl Carrier Protein
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Author Scienceshaman

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current23:07, 10 June 2015Thumbnail for version as of 23:07, 10 June 20151,650 × 1,275 (149 KB)Scienceshaman (talk | contribs)User created page with UploadWizard

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