File:Computational-Simulation-of-the-Activation-Cycle-of-Gα-Subunit-in-the-G-Protein-Cycle-Using-an-pone.0159528.s011.ogv

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file (Ogg multiplexed audio/video file, Theora/Vorbis, length 17 s, 1,920 × 1,080 pixels, 3.94 Mbps overall, file size: 7.84 MB)

Captions

Captions

Add a one-line explanation of what this file represents

Summary

[edit]
Description
English: Animation showing the hypothesized conformational changes of the G protein throughout the G protein cycle. The GDP-bound heterotrimer (gray) binds to activated receptor (blue), and the nucleotide-binding pocket region consisting of β6-α5, the P-loop and switch 2 are perturbation, resulting in GDP (purple) release. Subsequently, the helical domain of Gα(GDP) opens away from the receptor-anchored Ras domain, which allows GDP release and GTP (orange) to enter. Reorientation of Gα caused by GTP binding leads to dissociation of the receptor and Gβγ (Gβ; green and Gγ; cyan). GTP hydrolysis leads to rebinding of Gβγ to Gα in order to restart the G protein signaling cycle.
Date
Source S1 Video from Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M (2016). "Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model". PLOS ONE. DOI:10.1371/journal.pone.0159528. PMID 27483005. PMC: 4970668.
Author Kim M, Kim Y, Kim H, Jeon T, Choi J, Chung K, Kim M
Permission
(Reusing this file)
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Provenance
InfoField
This file was transferred to Wikimedia Commons from PubMed Central by way of the Open Access Media Importer.
WikiProject Open Access
WikiProject Open Access

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current20:38, 26 August 201617 s, 1,920 × 1,080 (7.84 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

You cannot overwrite this file.

Transcode status

Update transcode status
Format Bitrate Download Status Encode time
VP9 1080P 2.4 Mbps Completed 13:57, 22 August 2018 49 s
VP9 720P 984 kbps Completed 13:57, 22 August 2018 33 s
VP9 480P 474 kbps Completed 13:56, 22 August 2018 23 s
VP9 360P 266 kbps Completed 13:56, 22 August 2018 16 s
VP9 240P 144 kbps Completed 13:56, 22 August 2018 12 s
WebM 360P 518 kbps Completed 20:42, 26 August 2016 17 s
QuickTime 144p (MJPEG) 992 kbps Completed 18:52, 20 October 2024 1.0 s

Metadata

This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.

Retrieved from "https://commons.wikimedia.org/w/index.php?title=File:Computational-Simulation-of-the-Activation-Cycle-of-Gα-Subunit-in-the-G-Protein-Cycle-Using-an-pone.0159528.s011.ogv&oldid=866848542"