File:CRISPR Cas genome editing system.tif

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Captions

Captions

Cas12a (AsSpf1) in complex with crRNA and target DNA

Summary

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Description
English: CRISPR Cas12a (AsCpf1) system has been successfully harnessed for mammalian genome editing. AsCpf1 nuclease uses the single guide RNA to find a specific target sequence to introduce double-strand break. Then, the cell introduces a mutation at the site of the break through the repair mechanisms of damaged DNA.
Русский: CRISPR Cas12a (AsCpf1) система успешно используется для редактирования генома млекопитающих. Нуклеаза AsCpf1 с помощью направляющей РНК находит точное место в геноме, чтобы внести двухцепочечный разрыв. Затем клетка вносит мутацию в месте внесенного разрыва с помощью механизмов репарации поврежденной ДНК.
English: Cas12a in complex with crRNA and target DNA. Three-dimensional structure of Cas12(AsCpf1) ID 5B43 from the Protein Data Bank (PDB) database. Structural image was prepared with the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC and Adobe Illustrator.
Date
Source Own work
Author Elena I Leonova

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w:en:Creative Commons
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current21:13, 28 March 2020Thumbnail for version as of 21:13, 28 March 20204,938 × 5,909 (147.71 MB)Elena I Leonova (talk | contribs)Uploaded own work with UploadWizard

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