File:Bmp signaling induces Tbx2 expression in the limb bud mesenchyme.png
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Figure 5. Bmp signaling induces Tbx2 expression in the limb bud mesenchyme. (A, B) Whole mount in situ hybridization analysis demonstrates that Bmp4-soaked beads (100 µg/ml) but not BSA-soaked beads (control) induce Tbx2 expression in the central limb bud mesenchyme after 18 h of culture (black arrows). White asterisks show an expansion of Tbx2 expression into the proximal-central region following ectoderm removal. (C, D) Influence of Bmp signaling on Tbx2 expression in micromass cultures of dissociated E10.5 limb bud mesenchyme. Bmp4 (C) or the Bmp-inhibitor Dorsomorphin (D) was added during the last 2 hours of in total 18 hours of culture. The relative expression levels of Tbx2 and of the known Bmp targets Msx1 and Msx2 were analyzed by qPCR analysis. Means ± SD of four independent cDNAs. Significant changes compared to control are labeled with asterisks (*: p<0.05; **: p<0.01; ***: p<0.001, as determined by t-test). |
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| Source | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003467 Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. (2013) Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1. PLoS Genet 9(4): e1003467. https://doi.org/10.1371/journal.pgen.1003467 |
| Author | Farin HF, Lüdtke TH-W, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, et al. |
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© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 21:17, 15 November 2024 | | 2,853 × 3,069 (5.51 MB) | Rasbak (talk | contribs) | {{Information |Description=Figure 5. Bmp signaling induces Tbx2 expression in the limb bud mesenchyme. (A, B) Whole mount in situ hybridization analysis demonstrates that Bmp4-soaked beads (100 µg/ml) but not BSA-soaked beads (control) induce Tbx2 expression in the central limb bud mesenchyme after 18 h of culture (black arrows). White asterisks show an expansion of Tbx2 expression into the proximal-central region following ectoderm removal. (C, D) Influence of Bmp signaling on Tbx2 expressi... |
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