File:A-conserved-MCM-single-stranded-DNA-binding-element-is-essential-for-replication-initiation-elife01993v002.ogv

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English: Animation of a model for MCM to select the translocating strand during origin melting. Symmetric surfaces in different shades of green represent the two MCMN portions of a double hexamer. The dsDNA is first encircled by the MCM double hexamer. The dsDNA is driven toward the double hexamer interface by the dsDNA translocase activity of the AAA+ ATPase domains (not shown), which would be located above the light green surface and below the dark green surface. The dsDNA translocation creates strand separation where volume is available, enabling the MSSB to preferentially bind the strand with 5′→3′ clockwise polarity when viewed from the ATPase domain. Importantly, the MSSB-bound strand corresponds to the strand upon which the MCM helicase will translocate (magenta at top, cyan at bottom), as shown in Figure 7B, right panel.

DOI:

https://dx.doi.org/10.7554/eLife.01993.024
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Source Video 2. from Froelich C, Kang S, Epling L, Bell S, Enemark E (2014). "A conserved MCM single-stranded DNA binding element is essential for replication initiation". eLife. DOI:10.7554/eLife.01993. PMID 24692448. PMC: 3970758.
Author Froelich C, Kang S, Epling L, Bell S, Enemark E
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VP9 720P 193 kbps Completed 23:28, 15 August 2018 2.0 s
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QuickTime 144p (MJPEG) 174 kbps Completed 10:34, 14 October 2024 1.0 s

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