File:2024.01.08.574619.Fig5.png

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Giant virus endogenization events correlate with presence of 5-Methylcytosine (5mC) in eukaryotes.

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Description
English: Giant virus endogenization events correlate with presence of 5-Methylcytosine (5mC) in eukaryotes.
Left: Cladogram representing the lineages where large Giant Virus Endogenization Events (GEVEs) have been described in the literature, 5mC and Gene body Methylation pattern (GbM) presence. Dark dots indicate presence, white dots absence and brown dots indicate lack of data/studies.
Right: Schematic of the lateral gene transfers (LGT) from giant viruses to eukaryotes, and vice versa, mediated by chromatin regulatory mechanisms. DNA methyltransferases (DNMTs) mediate DNA methyl marks shown as lollipops.
Date
Source DNA methylation enables recurrent endogenization of giant viruses in an animal relative. PDF at https://www.researchgate.net/publication/377281311 (also available at bioRxiv:doi:10.1101/2024.01.08.574619, image almost identical with final release doi:10.1126/sciadv.ado6406 – final relase cladogram also includes Pigoraptor genus)
Author Luke A. Sarre, lana V. Kim, Vladimir Ovchinnikov, Marine Olivetta, Hiroshi Suga, Omaya Dudin, Arnau Sebé-Pedrós, Alex de Mendoza
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