File:Viruses-10-00340-g003.png

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Captions

Captions

Tick-borne encephalitis virus (TBEV) replicates efficiently inside membrane vesicular structures in the ER.

Summary

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Description
English: (Left) panel: in the absence of viperin, Tick-borne encephalitis virus (TBEV) replicates efficiently inside membrane vesicular structures in the ER. Assembled virions are secreted through the secretory pathway in a COPII and COPI dependent manner. (Right) panel: in the presence of viperin, TBEV replication is strongly reduced by viperin. Viperin targets the NS3 protein for proteasomal degradation which inhibits the synthesis of + strand RNA. Furthermore, NS3 interacts with E, NS2A, and NS2B and these proteins are degraded by viperin in a NS3-dependent manner. Viperin also interferes with particle assembly by inducing secretion of C particles in a COPII-dependent manner, independent of COPI. Viperin mediates this effect by interacting and sequestering GBF1. Red arrow = secretory pathway, blue arrow = “?” vesicular transport via unknown pathway.
Date
Source

Lindqvist, R.; Upadhyay, A.; Överby, A.K. Tick-Borne Flaviviruses and the Type I Interferon Response. Viruses 2018, 10, 340.

https://doi.org/10.3390/v10070340
Author Richard Lindqvist, Arunkumar Upadhyay, and Anna K. Överby

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