File:The Cononical miRNA biogenesis pathway.jpg

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English: The Cononical miRNA biogenesis pathway. pri-miRNAs are transcribed primarily as RNA pol II transcripts. The pri-miRNAs are processed co-transcriptionally by the Microprocessor (Drosha/Dgcr8). Following Microprocessor cleavage, Exportin-5 transports the pre-miRNA hairpin into the cytoplasm. There, the pre-miRNA is cleaved by Dicer, resulting in a miRNA/miRNA* complex. With the help of TRBP, the mature miRNA is loaded into the Argonaute subunit of the silencing complex. This complex then goes onto silence target mRNAs post-transcriptionally by translational inhibition and/or transcript destablization. Adapted from Babiarz et al., 2008.
Date Published May 31, 2009.
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StemBook Figure 1 The Cononical miRNA biogenesis pathway

  • Babiarz, J.E., and Blelloch R., Small RNAs – their biogenesis, regulation and function in embryonic stem cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.47.1, http://www.stembook.org.
Author Babiarz, J.E., and Blelloch R., Small RNAs – their biogenesis, regulation and function in embryonic stem cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.47.1, http://www.stembook.org.
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