File:Tau isoforms in the human brain.png
Jump to navigation
Jump to search
Size of this preview: 532 × 600 pixels. Other resolutions: 213 × 240 pixels | 426 × 480 pixels | 681 × 768 pixels | 908 × 1,024 pixels | 1,721 × 1,940 pixels.
Original file (1,721 × 1,940 pixels, file size: 590 KB, MIME type: image/png)
Captions
Captions
Tau isoforms in the human brain
Summary
[edit]
| Description |
English: Tau isoforms in the human brain.
(A) Schematic depiction of the formation of neurofibrillary tangles. Tau protein control stabilization of microtubules by kinases. Phosphorylated tau leads to microtubule disassembly. Irregular hyperphosphorylation of tau proteins results in the generation of insoluble tau oligomers, which then accumulate to form PHF, then NFT. (B) Schematic diagram of tau isoforms that are expressed in the adult human brain. MAPT gene encodes tau protein. The six tau isoforms are generated by splicing of exons 2, 3, and/or 10 that encode for N1 (blue), N2 (yellow), and R2 (red), respectively. The inclusion of exon 10 results in the generation of mRNA encoding 4R tau. The location of missense MAPT mutations utilized in the transgenic mice is shown. |
| Date | |
| Source | Yokoyama M, Kobayashi H, Tatsumi L and Tomita T (2022) Mouse Models of Alzheimer’s Disease. Front. Mol. Neurosci. 15:912995. doi: 10.3389/fnmol.2022.912995 |
| Author | Miyabishara Yokoyama, Honoka Kobayashi, Lisa Tatsumi, Taisuke Tomita |
Licensing
[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:08, 25 August 2024 | | 1,721 × 1,940 (590 KB) | MaligneRange (talk | contribs) | Uploaded a work by Miyabishara Yokoyama, Honoka Kobayashi, Lisa Tatsumi, Taisuke Tomita from Yokoyama M, Kobayashi H, Tatsumi L and Tomita T (2022) Mouse Models of Alzheimer’s Disease. Front. Mol. Neurosci. 15:912995. doi: 10.3389/fnmol.2022.912995 with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
