File:Protease mechanism summary.svg
Jump to navigation
Jump to search
Size of this PNG preview of this SVG file: 800 × 512 pixels. Other resolutions: 320 × 205 pixels | 640 × 410 pixels | 1,024 × 655 pixels | 1,280 × 819 pixels | 2,560 × 1,638 pixels | 1,225 × 784 pixels.
Original file (SVG file, nominally 1,225 × 784 pixels, file size: 529 KB)
Captions
Captions
Add a one-line explanation of what this file represents
Summary
[edit]
| Description |
English: A comparison of the two mechanisms used for proteolysis. enzyme is shown in black, substrate protein in red and water in blue.The top panel shows 1-step hydrolysis where the enzyme uses an acid to polarise water which then hydrolyses the substrate. The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate. This forms an intermediate where the enzyme is covalently linked to the N-terminal half of the substrate. In a second step, water is activated to hydrolyse this intermediate and complete catalysis. Other enzyme residues (not shown) donate and accept hydrogens and electrostatically stabilise charge build-up along the reaction mechanism. |
| Date | |
| Source | Thomas, Shafee, (2014). "Evolvability of a viral protease: experimental evolution of catalysis, robustness and specificity". PhD Thesis. University of Cambridge. |
| Author | Thomas Shafee |
Licensing
[edit]
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 05:20, 22 August 2015 | | 1,225 × 784 (529 KB) | Evolution and evolvability (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on bs.wikipedia.org
- Usage on en.wikipedia.org
- Usage on et.wikipedia.org
- Usage on ja.wikipedia.org
- Usage on zh.wikipedia.org
