File:Pleiotropic overlap between polygenic predictors (in variance accounted for).svg
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Captions
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Pleiotropy seems limited for many traits in humans since the SNP overlap, as measured by variance accounted for, between many polygenic predictors is small.
Summary
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| Description |
English: This table shows one measure of pleiotropy for many human traits. A polygenic predictor was trained on each trait and the overlap of the selected SNPs for each pair of predictors illustrated. The larger magnitude of overlap, i.e., pleiotropy, the more intense color in the table. Technically,
it shows the pairwise overlap between predictors in terms of the variance accounted for by predictor SNPs in common, expressed as a percentage of the total variance accounted for by the SNPs belonging to the predictor for the condition labelling each row. The overlapping variance is weighted according to the sign of the correlation between each pair of associated SNPs 4000 kilo base pairs or less apart. This can cause diagonal elements to be less than one hundred percent, as anti-correlated SNPs may be included in the overlap calculation. |
| Date | |
| Source | Yong, S.Y., Raben, T.G., Lello, L. et al. Genetic architecture of complex traits and disease risk predictors. Sci Rep 10, 12055 (2020). https://doi.org/10.1038/s41598-020-68881-8 |
| Author | Yong, S.Y., Raben, T.G., Lello, L., Hsu, S.D. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 12:54, 23 July 2021 | | 1,749 × 1,749 (601 KB) | Stal potaten (talk | contribs) | Uploaded a work by Yong, S.Y., Raben, T.G., Lello, L., Hsu, S.D. from Yong, S.Y., Raben, T.G., Lello, L. et al. Genetic architecture of complex traits and disease risk predictors. Sci Rep 10, 12055 (2020). https://doi.org/10.1038/s41598-020-68881-8 with UploadWizard |
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