File:Non-Mendelian inheritance of mouse paramutations.png

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Русский: Схема наследования парамутации Kit у мышей. Скрещивание гетерозиготы Kittm1Alf/+ (Kit) с мышью дикого типа приводит к появлению потомства с характерными белыми хвостами и лапами. Когда эти мыши снова скрещиваются с мышами дикого типа, часть потомства наследует "белый" фенотип даже при генотипе дикого типа. Такой фенотип также получается при микроинъекции РНК в оплодотворённое яйцо, что подтверждает важную роль РНК в описанном выше наследовании
English: The “white-spotted” Kittm1Alf/+ mouse phenotype provides an important paradigm for RNA-mediated non-Mendelian inheritance. Mating of heterozygous Kittm1Alf/+ (Kit) mice with wild-type (wt) mice results in Kittm1Alf/+ (Kit) offspring with characteristic white tails and feet. When these mice are again mated with wild-type mice, a fraction of the offspring retains the “white-spotted” phenotype, even with a wild-type genotype. This phenotype could also be induced by microinjection of RNA into fertilized oocytes, which suggests that RNA plays an important role in the mechanism of inheritance.
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Source http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004296
Author Reinhard Liebers, Minoo Rassoulzadegan, Frank Lyko

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