File:NF-kB LUBAC.png

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Català: Regulació de la via metabòlica del complex proteic NF-kB. S'observen els passos fonamentals d'activació del complex NF-kB.

1. Es produeix unió lligand-receptor. 2. La unió lligand-receptor indueix la síntesi de cadenes Met1-Ub. 3. La proteïna NEMO s'ubiquitina amb les cadenes Met1-Ub. 4. La proteïna ubiquitinada NEMO activa la quinasa IKKα/β.

5. La quinasa, al mateix temps, activa el complex NF-kB, el qual participa en vàries respostes cel·lulars. Un cop s'ha produït l'activitat catalítica, la quinasa es degrada en un proteosoma.
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Author BQUB1819-HHuang

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