File:Myofibrillary myopathy histology.jpg

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Captions

Muscle biopsy findings in various MFM subtypes

Summary

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Description
English: (A) HE stain in BAG3opathy showing intramuscular eosinophilic deposits (B-D) Immunohistochemial stains (respectively: desmin, BAG3 αB crystallin) on serial sections showing MFM-protein accumulation. (E) HE stain in filaminopathy showing fiber size variation and rare regeneration. (F) HE stain in FHL1opathy showing eosinophilic material and small fiber size. (G) HE stain in HMERF showing vacuolated fibers (arrow), central nucleated fibers, and nuclear clumps. (H) Gomori stain showing necklace cytoplasmic bodies. (I) HE in titinopathy showing central nuclei and selective type 1 atrophy. (J) NADH stain in same titinopathy patient. (K) HE in titinopathy showing rimmed vacuoles (arrow) and esosinophilic bodies (arrowhead). (L) NADH in same titinopathy patient, showing occasional bar-like enzyme aggregation (arrow). Magnification 200x
Date
Source Expanding the Clinico-Genetic Spectrum of Myofibrillar Myopathy: Experience From a Chinese Neuromuscular Center. (2020) Front. Neurol. 11:1014. doi: 10.3389/fneur.2020.01014
Author Luo Y-B, Peng Y, Lu Y, Li Q, Duan H, Bi F and Yang H

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