File:MicroRNAs are integral to transcription networks in ESCs..jpg
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MicroRNAs_are_integral_to_transcription_networks_in_ESCs..jpg (415 × 287 pixels, file size: 50 KB, MIME type: image/jpeg)
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DescriptionMicroRNAs are integral to transcription networks in ESCs..jpg |
English: The circuit map that integrates transcription regulation and microRNA functions is constructed based on existing data. A core set of TFs regulates themselves, as well as the expression of microRNAs. MicroRNAs, whose expressions are positively regulated, are frequently associated with self-renewal, whereas those negatively regulated in ESCs are associated with differentiation. In addition, microRNAs feedback into the transcription circuitry through post-transcriptional modulation of their TF targets, controlling their levels and activity. Several other microRNAs appear to have roles in either self-renewal or differentiation, but their upstream regulators have yet been identified. |
Date | Published September 15, 2008. |
Source |
[1] Direct
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Author | Tam, W.-L. and Lim, B., Genome-wide transcription factor localization and function in stem cells (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.19.1, http://www.stembook.org. |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 18:59, 5 April 2013 | 415 × 287 (50 KB) | Smallbot (talk | contribs) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 121/173 |
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