File:Liver Chip (33258222594).png

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Liver_Chip_(33258222594).png (556 × 277 pixels, file size: 216 KB, MIME type: image/png)

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Description

The above images show human liver cells (blue) and breast cancer cells (red) in the LiverChip model.

The image on the left shows the cells after they were treated with a chemotherapy drug called doxorubicin (DOX). The breast cancer cells are dormant (not multiplying), but they are still alive after DOX treatment in the bioengineered system. However, as shown in the image on the right, when the scientists mimic inflammation using a substance called lipopolysaccharide and a growth factor along with the DOX chemotherapy, the cells come out of dormancy and start to multiply. This experiment shows that the LiverChip is an effective system for replicating the conditions under which dormant cancer cells in the liver become activated and start to grow.

Credit: University of Pittsburgh and Massachusetts Institute of Technology
Date
Source Liver Chip
Author National Center for Advancing Translational Sciences from Bethesda, MD

Licensing

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Public domain This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, taken or made as part of an employee's official duties. As a work of the U.S. federal government, the image is in the public domain.
Please ensure that this image was actually created by the US Federal government. The NIH frequently uses commercial images which are not public domain.
This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights.


This image was originally posted to Flickr by NIH-NCATS at https://flickr.com/photos/64860478@N05/33258222594. It was reviewed on 16 November 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the Public Domain Mark.

16 November 2020

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Date/TimeThumbnailDimensionsUserComment
current10:41, 10 November 2020Thumbnail for version as of 10:41, 10 November 2020556 × 277 (216 KB)Netha Hussain (talk | contribs)Transferred from Flickr via #flickr2commons

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