File:Ligand Probe Crosslinker Immobilization.png

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file (3,000 × 3,057 pixels, file size: 629 KB, MIME type: image/png)

Captions

Captions

Illustration of target identification using various immobilization strategies.

Summary

[edit]
Description
English: A. A small molecule is derivatized for immobilization on a solid support, such as a magnetic bead or affinity column. Protein targets bind to the small molecule and can be identified after elution.

B. A small molecule is attached to an enrichment handle. The enrichment handle is then used to pull down the small molecule-protein complex.

C. A small molecule molecule is functionalized with a cross-linking group and an enrichment handle. After a target binds the small molecule, the cross-linking group can be activated, often by light, forming a covalent bond between target and small molecule. The enrichment handle is then used to pull down the small molecule-protein complex.
Date
Source BioRender.com
Author BioRender.com

Licensing

[edit]
w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current18:23, 6 December 2021Thumbnail for version as of 18:23, 6 December 20213,000 × 3,057 (629 KB)Sgold626 (talk | contribs)Uploaded a work by BioRender.com from BioRender.com with UploadWizard

You cannot overwrite this file.

There are no pages that use this file.

Metadata

This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.

Retrieved from "https://commons.wikimedia.org/w/index.php?title=File:Ligand_Probe_Crosslinker_Immobilization.png&oldid=653929164"