File:JAK-STAT-signaalroute.png
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Nederlands: De JAK–STAT-signaalroute. Na binding van een cytokine raken twee receptoren gedimeriseerd en zodanig geheroriënteerd dat de geassocieerde JAK’s bij elkaar gebracht worden en elkaar fosforyleren. Ze raken geactiveerd en fosforyleren de receptoren en creëren daarbij docking sites voor SH2-domeinen van STAT-eiwitten. De STAT-eiwitten vormen een dimeer en gaan naar de celkern om daar genexpressie te reguleren. |
| Date | |
| Source | Own work |
| Author | TheBartgry |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 22:27, 5 May 2024 | | 2,064 × 1,610 (984 KB) | TheBartgry (talk | contribs) | Uploaded own work with UploadWizard |
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