File:Influence of pigmentation on skin cancer risk.png
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Summary
[edit]DescriptionInfluence of pigmentation on skin cancer risk.png |
English: Influence of pigmentation on skin cancer risk. Fair-skinned individuals with low levels of melanin in the epidermis display a UV sensitive phenotype, tending to burn rather than tan, after UV exposure. Recent data suggest that mutations that contribute to fair complexion and tanning impairment, specifically signaling defects in the melanocortin 1 receptor (MC1R), may also be associated with less efficient DNA repair in melanocytes. MC1R-defective individuals not only suffer higher realized doses of UV radiation because their skin is less able to block UV photons, but they may also accumulate more mutations from UV exposure because of defective DNA repair. |
Date | Published: 7 June 2013 |
Source | John D’Orazio et al. "UV Radiation and the Skin" Int. J. Mol. Sci. 2013, 14(6), 12222-12248; doi:10.3390/ijms140612222 http://www.mdpi.com/1422-0067/14/6/12222/htm |
Author | John D’Orazio, Stuart Jarrett, Alexandra Amaro-Ortiz and Timothy Scott |
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[edit]This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 04:56, 18 April 2021 | 1,276 × 490 (260 KB) | JPxG (talk | contribs) | fix strange, extraterrestrial eyes | |
00:13, 18 January 2018 | 1,276 × 490 (273 KB) | Erulas (talk | contribs) | Reverted to version as of 00:07, 18 January 2018 (UTC) | ||
00:13, 18 January 2018 | 2,754 × 1,054 (8.31 MB) | Erulas (talk | contribs) | Accidentally uploaded the original rather than the edited file | ||
00:07, 18 January 2018 | 1,276 × 490 (273 KB) | Erulas (talk | contribs) | Removed lazy and inaccurate racial categories that accompanied the skin tone types. Asians and Native Americans were glossed over as homogeneous categories even though their skin tones span nearly the entire Fitzpatrick scale. Austronesians were crudel... | ||
20:09, 23 June 2016 | 2,754 × 1,447 (555 KB) | Was a bee (talk | contribs) | {{Information |Description={{en|1=Influence of pigmentation on skin cancer risk. Fair-skinned individuals with low levels of melanin in the epidermis display a UV sensitive phenotype, tending to burn rather than tan, after UV exposure. Recent data sugg... |
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Unique ID of original document | xmp.did:559b720e-259f-4fe3-8511-c6fd7074fa33 |
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Software used | GIMP 2.10 |
Horizontal resolution | 196.85 dpc |
Vertical resolution | 196.85 dpc |
File change date and time | 04:55, 18 April 2021 |