File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450fs009.jpg
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[edit]DescriptionGE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450fs009.jpg |
English: Superimposition of crystal structures of RPo-GE, RPo-GpA, and the transcription elongation complex: predicted steric clash between GE and NTPs in i and i+1 sites. Blue mesh, blue sticks, red sticks, gray ribbon: mFo-DFc omit map for GE, atomic model for GE, DNA template strand, and RNAP bridge helix from crystal structure of RPo-GE (Figure 4). Upper pink sticks and violet sphere: RNA 3' nucleotide in i site and Mg2+(I) from crystal structure of RPo-GpA (Zhang et al., 2012). Lower pink sticks and violet sphere: NTP in i+1 site and Mg2+(II) from crystal structure of the transcription elongation complex (Vassylyev et al., 2007). |
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Source | Image file from Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R (2014). "GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides". eLife. DOI:10.7554/eLife.02450. PMID 24755292. PMC: 3994528. | |
Author | Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R | |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 12:11, 30 July 2014 | 760 × 685 (146 KB) | Recitation-bot (talk | contribs) | Automatic upload of media from: doi:10.7554/eLife.02450 |
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Horizontal resolution | 600 dpi |
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Number of components | 3 |
Image width | 1,140 px |
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Color space | Uncalibrated |
Software used | Adobe Photoshop CS4 Windows |
Date and time of digitizing | 21:39, 3 April 2014 |
File change date and time | 13:33, 5 April 2014 |
Date metadata was last modified | 13:33, 5 April 2014 |
Unique ID of original document | xmp.did:E30A0C656ABCE311B974E0B278369CE4 |