File:Fluorescence Imaging 05.jpg
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Deutsch: Die Anreicherung von STL-6014, einem Bakteriochlorophyll (BChl), das mit einer RGD-Sequenz konjugiert wurde, im nekrotischen Gewebe eines orthotopen Brustkrebstumors vom Typ MDA-MB-231-RFP (RPF rotfluoreszierendes Protein), der in CD-1-Nacktmäuse implantiert wurde. 15 mg/kg KGW STL-6014 wurden intravenös appliziert. Die Aufnahmen entstanden vier Stunden nach der STL-6014-Injektion. Die Aufnahme A zeigt den Tumor im Tageslicht. Bild C ein Fusionsbild aus NIR- und SW-Tageslichtaufnahme. Bild D zeigt den exzidiertern Tumor im Tageslicht und Bild F das Fusionsbild. ND sind die nekrotischen Bereiche des Tumors, VD die lebensfähigen Bereiche.
English: STL-6014 accumulation in the necrotic area of large orthotopic MDA-MB-231-RFP tumors. CD-1 nude, female mice (n 3) bearing an orthotopically grafted, large MDA-MB-231-RFP tumor were intravenously injected with 15 mg/kg STL-6014. Whole-body and excised tumor images were taken at 4 hours, 16 hours, and 3 days post-injection. Upper panels - in vivo images, lower panels - images of excised tumors. (a and d) Color photos. (b and e) Red fluorescence images for detection of tumor location and size. (c anf f) near infrared (NIR) fluorescence images for detection of STL-6014 distribution. All other details are as described in the methods section. ND, necrotic domain, VD, viable domain. |
| Date | published 24 May 2010 |
| Source | Liat Goldshaid, Efrat Rubinstein, Alexander Brandis, Dadi Segal, Noa Leshem, Ori Brenner, Vyacheslav Kalchenko, Doron Eren, Tamar Yecheskel, Yoseph Salitra, Yoram Salomon and Avigdor Scherz: Novel design principles enable specific targeting of imaging and therapeutic agents to necrotic domains in breast tumors. In: Breast Cancer Research 2010, 12:R29doi:10.1186/bcr2579 Open Access |
| Author | Liat Goldshaid, Efrat Rubinstein, Alexander Brandis, Dadi Segal, Noa Leshem, Ori Brenner, Vyacheslav Kalchenko, Doron Eren, Tamar Yecheskel, Yoseph Salitra, Yoram Salomon and Avigdor Scherz |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:17, 19 September 2012 | | 1,724 × 1,653 (1.45 MB) | McZusatz (talk | contribs) | copied image data from firefox into GIMP |
| 17:42, 23 June 2010 |  | 1,724 × 1,653 (1.16 MB) | Kuebi (talk | contribs) | {{Information |Description={{de|Die Anreicherung von STL-6014, einem Bakteriochlorophyll (BChl), das mit einer RGD-Sequenz konjugiert wurde, im nekrotischen Gewebe eines orthotopen Brustkrebstumors vom Typ MDA-MB-231-RFP (RPF=rotfluoreszierendes Protein), |
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