File:Eigengenes following Alter et al. PNAS 2000 and Alter and Golub PNAS 2006.png

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Eigengenes computed by the SVD of a genes x samples matrix that tabulates, e.g., the mRNA expression of the genes across the samples.

Summary

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Description
English: Eigengenes computed by the SVD of a genes x samples matrix that tabulates the mRNA expression of human genes across gel electrophoresis samples.

Following:

1. Orly Alter et al., ‘‘Singular value decomposition for genome-wide expression data processing and modeling,’’ PNAS 97, 10101 (2000); https://doi.org/10.1073/pnas.97.18.10101

See also 1999, Orly Alter et al., ‘‘Singular Value Decomposition for Gene Expression Data Processing and Modeling.’’ In: After the Genome V (1999, Jackson Hole, WY), published by the U.S. DOE; https://osti.gov/servlets/purl/803995

2. Orly Alter and Gene H. Golub, "Singular Value Decomposition of Genome-Scale mRNA Lengths Distribution Reveals Asymmetry in RNA Gel Electrophoresis Band Broadening," PNAS 103, 11828 (2006); https://doi.org/10.1073/pnas.0604756103

See also Nicolas M. Bertagnolli, et int., Orly Alter, "SVD Identifies Transcript Length Distribution Functions from DNA Microarray Data and Reveals Evolutionary Forces Globally Affecting GBM Metabolism," PLoS One 8, e78913 (2013); https://doi.org/10.1371/journal.pone.0078913
Date
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Author ILAS2023

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