File:Cells-11-03214-g001-550.webp

English: Figure 1. Anticoagulants and their targets within the coagulation cascade. The coagulation cascade consists of three parts: the tissue factor (TF) pathway, the contact activation pathway, and the common pathway. Currently used anticoagulants target primarily coagulation factors from the common pathway: FXa (apixaban, edoxaban, fondaparinux, and rivaroxaban) and thrombin (FIIa; dabigatran, bilvalirudin, and argatroban). UFH, VKA, and LMWH have multiple targets within the coagulation cascade. Anticoagulants that are currently under development or undergoing clinical trials target factors from the TF pathway (TF-FVIIa complex) or the contact activation pathway (FIXa, FXIa, and FXIIa). Tenase complex: FVIIIa-FIXa complex. Prothrombinase complex: FVIIIa-FIXa-FXa complex.