File:Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment (MédiHAL 3955423).jpg

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Catalysis_Driven_Six-Step_Synthesis_of_Apratoxin_A_Key_Polyketide_Fragment_(MédiHAL_3955423).jpg (299 × 210 pixels, file size: 8 KB, MIME type: image/jpeg)

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Captions

Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation.

Summary

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Description
English: Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redox-economical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a site-selective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.
Date Taken on 16 September 2022
Source Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment
Author

Na Shao, Jean Rodriguez, Adrien Quintard

Adrien Quintard   wikidata:Q81717626
 
Description researcher
Authority file
creator QS:P170,Q81717626
institution QS:P195,Q30295259
institution QS:P195,Q2302586
institution QS:P195,Q3152386
institution QS:P195,Q280413
institution QS:P195,Q30261526
institution QS:P195,Q945876
Keywords
InfoField
Enantioselective; Total synthesis polyketide; Multicatalysis; Catalysis; Anticancer

Licensing

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Public domain
This work is in the public domain in France for one of the following reasons:
  • Its author (or the last of its authors in the case of a collaboration work) died more than 70 years ago (CPI art. L123-1) and did not benefit from any copyright extension (CPI art. L123-8, L123-9 and L123-10)[1];
  • It is an anonymous or pseudonymous work (the identity of the author has never been disclosed) or a collective work[2] and more than 70 years have passed since its publication (CPI art. L123-3);
  • It is the recording of an audiovisual or musical work already in the public domain, and more than 50 years have passed since the performance or the recording (CPI art. L211-4).
Please note that moral rights still apply when the work is in the public domain. They encompass, among others, the right to the respect of the author's name, quality and work (CPI art. L121-1). Attribution therefore remains mandatory.
  1. ↑ Copyright extensions must be considered only in the case of musical works and of authors Mort pour la France (died during conflict, in the service of France). In other cases, they are included in the 70 years post mortem auctoris length (see this statement of the Cour de Cassation).
  2. ↑ The collective work status is quite restrictive, please make sure that it is actually established.

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