File:Archives of physical medicine and rehabilitation (1920) (14757185455).jpg

Identifier: archivesofphysic04ameruoft (find matches)
Title: Archives of physical medicine and rehabilitation
Year: 1920 (1920s)
Authors: American Academy of Physical Medicine and Rehabilitation American College of Radiology and Physiotherapy American Congress of Physical Medicine and Rehabilitation Radiological Society of North America
Subjects: Physical therapy
Publisher: (Chicago, etc.)
Contributing Library: Gerstein - University of Toronto
Digitizing Sponsor: University of Toronto

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examined early, only inflammatoryreactions and papillomas are found.But even as early as 1913 Fibiger hadfound 5 cases of cancer in rats fed onnematode-infected cockroaches and hehas found many since. He says ofthese early observations: In 5 laboratory rats fed on cockroaches(in 4 cases P. amcricana, in I case P. orien-*.alh) microscopical exammation of the car-diac portion of the stomach showed processeswhich differed from those in the other rats.The c/innges, in fad, /lerc appeared to betrue cancerous grorvths, ttie mucous membraneand submucosa tiaving cfiangcd into a tumorllsiuc of quite the same t^pe as is gencra//)ifouiul in true squamous-celted carcinoma in In two of these rats carcinomatous metas-tases were observed in a lymph gland and ina lung respectively; in a third case the urinarybladder contained papillomatous growth whichwas probably a metastasis too. Notwithstandinga very careful examination of serial sections 303 TWKXTIETH PEXTrRV ADVANCES IX CAX( ER RESEARCH—SMITH
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-0. 22^Pho1Vr«;he°/il\^7r,-3<, V. Inocu.a.ed FeL.». iJ^., The plnnt« nre In a ^04 Hir, .M:i TWENTIETH CENTURY ADVANCES IN CANCER RESEARCH—SMITH neither nematodes nor eggs were found in anyof these metastases, being thus metastases inthe most strict sense of the term. By Ihae inveiligalions carcinomalous tum-ours giving rise to metastases Jverc producedexperimentally for the first time, and the hy-polheiis put fonuarj by Barrel and Haalandaas thus verified, as it has now been provedthat nematodes play a causal part in thedevelopment of cancer in rats. Dr. Fibiger was led to make thesestudies by finding in 1907 in the stom-achs of three captive wild rats (A/usdecumanus) enormous papillomas asso-ciated with a nematode and showingcarcinomatous tendencies. These ratswhich belonged to the AnatomicalPathological Institute were probablyimported from Dorpat (Russia). Thisdiscovery led to the examination of.numerous Danish wild rats and ofblack and white rats from various lab-oratories

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