File:APP metabolism by the secretase enzymes.jpg
Jump to navigation
Jump to search
No higher resolution available.
APP_metabolism_by_the_secretase_enzymes.jpg (720 × 540 pixels, file size: 47 KB, MIME type: image/jpeg)
Captions
Captions
Add a one-line explanation of what this file represents
| Description |
English: APP metabolism by the secretase enzymes. APP is sequentially cleaved by BACE1, the β-secretase, and γ-secretase, a complex comprised of presenilin, nicastin, Aph1 and Pen2, to generate Aβ. BACE1 cleavage of APP is a prerequisite for Aβ formation and is putatively the rate-limiting step in Aβ genesis. BACE1 cleavage of APP forms the N-terminus of the peptide, and two cleavage fragments are liberated: APPsβ, a secreted ectodomain, and C99, a membrane bound fragment. C99 is the substrate for γ-secretase, and C99 cleavage generates the AICD together with the C-terminus of Aβ. Aβ formation is prevented by the activities of α-secretase, which has been identified as TACE, ADAM9 and ADAM10. α-secretase cleaves APP to generate the secreted ectodomain, APPsα and membrane bound fragment, C83. C83 is subsequently cleaved by the γ-secretase complex to yield the 3 KDa fragment, P3 and the AICD.
|
| Date | |
| Source | The Alzheimer's disease β-secretase enzyme, BACE1 |
| Author | Sarah L Cole and Robert Vassar |
| Permission (Reusing this file) |
© 2007 Cole and Vassar; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
This file is licensed under the Creative Commons Attribution 2.5 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 02:03, 25 July 2009 | | 720 × 540 (47 KB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=APP metabolism by the secretase enzymes. APP is sequentially cleaved by BACE1, the β-secretase, and γ-secretase, a complex comprised of presenilin, nicastin, Aph1 and Pen2, to generate Aβ. BACE1 cleavage of APP is a pr |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on bs.wikipedia.org
- Usage on en.wikipedia.org
- Usage on ru.wikipedia.org
