File:991 activator binding to AMPK Fig2a.gif
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English: "BLI data (average of four traces) for the binding of 991 (1.5 μM) to α1β1γ1. A double exponential fit (blue) gave kobs=0.148 s−1. The dependence of kobs on the concentration of 991 (inset) gave a kon value of 0.103±0.008 μM−1s−1 (average of 4 traces). Analysis of the dissociation phase (see Supplementary Methods) gave koff=0.0062±0.0012, s−1, giving a Kd of 0.06±0.012 μM for the binding of 991 to α1β1γ1." Figure 2a from B.Xiao et al. "Structural basis of AMPK regulation by small molecule activators" Nature Communications 4 doi:10.1038/ncomms4017 . Image and description copied under CC-BY 3.0 licence. |
| Date | |
| Source | http://www.nature.com/ncomms/2013/131219/ncomms4017/full/ncomms4017.html |
| Author | Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, Lesley F. Haire, Elizabeth Underwood, Bhakti R. Patel, Richard B. Heath, Philip A. Walker, Stefan Hallen, Fabrizio Giordanetto, Stephen R. Martin, David Carling & Steven J. Gamblin |
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| current | 15:54, 14 November 2014 | | 861 × 888 (31 KB) | MartinPoulter (talk | contribs) | User created page with UploadWizard |
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