File:41467 2018 7531 Fig1 HTML.jpg

English: Cryo-EM structures of CVA10 mature virus, empty- and A-particles. a Three-dimensional reconstructions of CVA10 mature virus, empty- and A-particles viewed along the icosahedral twofold axes. The surfaces are colored radially from blue through green to red from the lowest to the highest radius. One icosahedral asymmetric unit is marked with a black triangle in CVA10 mature virus; icosahedral symmetry axes are drawn in black. The obstructed off-axis channels near the twofold axes in CVA10 A-particle are highlighted in magenta. b Thin slices of the central sections of the CVA10 mature virus, empty- and A-particles viewed down the threefold axes, colored radially from blue through green to red from the lowest to the highest radius. The scale bar applies to both a and b. c Cartoon of the mature CVA10 virus looking down an icosahedral twofold axis (left). The color scheme uses the signature colors (VP1, blue; VP2, green; VP3, red). A single icosahedral protomer is drawn more brightly and the electron density map (gray) for this protomeric unit is accentuated in inset (right). d Electron density maps from a section of VP1, VP2, and VP3, respectively. e Superimpositions of VP1, VP2, and VP3 from CVA10 mature virus, empty- and A-particles, respectively. VP1, VP2, VP3, and VP4 of CVA10 mature virus are colored using classic color scheme, VPs from CVA10 empty particle are shown in magenta, VPs of CVA10 A-particle are displayed in cyan, as shown by the color bars. N-and C-terminus of each protein are labeled in correspondingly colored letters; termini that are overlaid or near are labeled in black letters