File:11886 2020 1427 Fig1 HTML.webp
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Inclisiran
Summary
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| Description |
English: Inclisiran: mechanism of action. Inclisiran is a long-acting, synthetic siRNA directed against proprotein convertase subtilisin-kexin type 9 (PCSK9), conjugated to triantennary N-acetylgalactosamine carbohydrates, which bind to abundant liver-expressed asialoglycoprotein receptors, leading to a rapid uptake of inclisiran specifically into hepatocytes. Inclisiran engages the natural pathway of RNA interference (RNAi) by binding to the RNA-induced silencing complex (RISC) intracellularly, enabling it to catalytically cleave PCSK9 messenger RNA (mRNA), which itself is then degraded, inhibiting translation into PCSK9. With less PCSK9 available, more low-density lipoprotein-cholesterol (LDL-C) receptors can be recycled to the hepatic membrane for LDL-C uptake |
| Date | |
| Source | https://link.springer.com/article/10.1007/s11886-020-01427-6 |
| Author | David Sinning , Ulf Landmesser |
Licensing
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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- to share – to copy, distribute and transmit the work
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- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 22:54, 26 February 2024 | | 685 × 452 (41 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by David Sinning , Ulf Landmesser from https://link.springer.com/article/10.1007/s11886-020-01427-6 with UploadWizard |
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